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Web1.4 계산 공식. C0: C0 is the initial concentration at the dosing time.It is the observed concentration at the dosing time, if available. Otherwise it is approximated using the following rules. For iv-bolus data, log-linear back-extrapolation (see “backExtrap” argument) is performed from the first two observations to estimate C0, provided the local slope is … WebMean steady-state nicotine and cotinine area under the curve (AUC0-24), maximum plasma concentration (Cmax), minimum plasma concentration (Cmin), average plasma concentration (Cavg), and total urinary cotinine were proportional to the dose of nicotine released in vitro from Nicotine Transdermal System. knife test field
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